Treatment of lymphatic malformations in children: 10 years of experience

Purpose is to identify the factors that determine clinical features of LMs, their complications and choice treatment options. Materials methods. 225 children with LMs who underwent since 2011 2020 were enrolled. They grouped according ISSVA 2018 classification. Clinical presentation, options, outcomes analyzed. One-variant analysis using Pearson’s χ2 test was used evaluate qualitative data. Results. 214 (95.1%) patients had cystic 11 (4.9%) combined LMs. 129 (57.3%) cervicofacial, 17 (11.9%) developed airways compression 6 (4.2%) required tracheostomy. 8 (3.6%) 10 lymphatic leaks episodes, 3 lethal. 112 (86.8%) 5 (11.6%) abdominal, (84.6%) axillar, 12 (92.2%) extremities sclerotherapy. Surgical resections prevailed in abdominal 32 (74.5%), versus 4 (3.1%) cervicofacial (4.4%) complicated systemic sirolimus therapy. Results excellent 116 (51.6%) patients, good 82 (36.4%), satisfactory 23 (10.2%), unsatisfactory (1.8%), mortalities caused by sepsis (n=1) massive lymph leakage (n=3). Conclusions. The most life-threatening are uncontrollable leakages. Several approaches used, including surgery, sclerotherapy, target Surgery optional for but potentially harmful cervicofacial. Treatment LM continuous requires a combination different research carried out accordance principles Helsinki Declaration. study protocol approved Local Ethics Committee all participating institutions. informed consent patient obtained conducting studies. No conflict interests declared authors. Keywords: malformations, children,